CCL2/CCR2 Expression in Locally Advanced Prostate Cancer and Patient Long-Term Outcome: 10-Year Results from the TROG 03.04 RADAR Trial

Marsland, Mark; Jiang, Chen Chen; Faulkner, Sam; Steigler, Allison; McEwan, Kristen; Jobling, Phillip; Oldmeadow, Christopher; Delahunt, Brett; Denham, James W.; Hondermarck, Hubert

Title: CCL2/CCR2 Expression in Locally Advanced Prostate Cancer and Patient Long-Term Outcome: 10-Year Results from the TROG 03.04 RADAR Trial
Creator: Marsland, Mark; Jiang, Chen Chen; Faulkner, Sam; Steigler, Allison; McEwan, Kristen; Jobling, Phillip; Oldmeadow, Christopher; Delahunt, Brett; Denham, James W.; Hondermarck, Hubert
Relation: NHMRC.2020111 https://purl.org/au-research/grants/nhmrc/2020111
Relation: Cancers Vol. 16, Issue 16, no. 2794
Publisher Link: http://dx.doi.org/10.3390/cancers16162794
Publisher: MDPI AG
Resource Type: journal article
Date: 2024
Description: This study investigated the prognostic value of the chemokine C-C motif ligand 2 (CCL2) and its receptor C-C motif chemokine receptor 2 (CCR2) expression in locally advanced prostate cancer treated with radiotherapy and androgen deprivation using the 10-year outcome data from the TROG 03.04 RADAR clinical trial. CCL2 and CCR2 protein expression in prostate cancer biopsies at the time of diagnosis were quantified by immunohistochemistry and digital quantification. CCR2 protein expression was detected in prostate cancer cells and was associated with prostate-specific antigen serum concentration (p = 0.045). However, neither CCL2 nor CCR2 tissue expression could predict prostate cancer progression, or other clinicopathological parameters including perineural invasion and patient outcome. In serum samples, CCL2 concentration at the time of diagnosis, as assayed by enzyme-linked immunosorbent assay, was significantly higher in patients with prostate cancer compared with benign prostatic hyperplasia (median difference 0.22 ng/mL, 95% CI, 0.17–0.30) (p < 0.0001) and normal controls (median difference 0.13 ng/mL, 95% CI, 0.13–0.17) (p < 0.0001). However, circulating CCL2 was not statistically significant as a predictor of disease progression and patient outcome. In conclusion, this study shows that although CCL2 and CCR2 are expressed in prostate cancer, with an increased level of CCL2 in the serum, neither CCL2 nor CCR2 expression has a clinical prognostic value in locally advanced prostate cancer.
Subject: prostate cancer; CCL2; CCR2; cancer biomarker; RADAR trial; SDG 3; Sustainable Development Goal
Identifier: http://hdl.handle.net/1959.13/1517717
Identifier: uon:57168
Identifier: ISSN:2072-6694
Rights: x
Language: eng
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